Helicopter noise research at the Langley V/STOL tunnel

The noise generated from a 1/4-scale AH-1G helicopter configuration was investigated in the Langley V/STOL tunnel. Microphones were installed in positions scaled to those for which flight test data were available. Model and tunnel conditions were carefully set to properly scaled flight conditions. Data presented indicate a high degree of similarity between model and flight test results. It was found that the pressure time history waveforms are very much alike in shape and amplitude. Blade slap when it occurred seemed to be generated in about the same location in the rotor disk as on the flight vehicle. If model and tunnel conditions were properly matched, including inflow turbulence characteristics, the intensity of the blade-slap impulse seemed to correlate well with flight

Longitudinal aerodynamics of a low-wing lift-fan transport including hover characteristics in and out of ground effect

A wind-tunnel investigation was conducted in the Langley V/STOL tunnel to determine the longitudinal aerodynamic characteristics of a six-fan, tip-driven (remote) lift-fan VTOL transport throughout transition. The large midspan lift-fan pods and cruise fans were removed to determine their influence on the stability and control of the configuration. Data were obtained in the hovering mode for ranges of model height above ground. The data are presented without analysis or discussion

Longitudinal aerodynamic characteristics of a low-wing lift-fan transport including hover characteristics in and out of ground effect

The longitudinal aerodynamic characteristics of a six-fan, tip-driven (remote) lift-fan VTOL transport through transition were determined by an investigation conducted in the Langley V/STOL tunnel. Tests were also made with the large midspan lift-fan pods and lift-cruise fans removed to determine their their influence on the stability and control of the configuration. Data were obtained for a range of model height above ground

Design and testing of microbubble‐based MRI contrast agents for gastric pressure measurement

Purpose: This work demonstrates specifically tailored microbubble‐based preparations and their suitability as MRI contrast agents for ingestion and measuring temporal and spatial pressure variation in the human stomach. Methods: Enhanced alginate spheres were prepared by incorporating gas‐filled microbubbles into sodium alginate solution followed by the polymerization of the mixture in an aqueous calcium lactate solution. The microbubbles were prepared with a phospholipid shell and perfluorocarbon gas filling, using a mechanical cavitational agitation regime. The NMR signal changes to externally applied pressure and coming from the enhanced alginate spheres were acquired and compared with that of alginate spheres without microbubbles. In vivo investigations were also carried out on healthy volunteers to measure the pressure variation in the stomach. Results: The MR signal changes in the contrast agent exhibits a linear sensitivity of approximately 40% per bar, as opposed to no measurable signal change seen in the control gas‐free spheres. This novel contrast agent also demonstrates an excellent stability in simulated gastric conditions, including at body temperature. In vivo studies showed that the signal change exhibited in the meal within the antrum region is between 5% and 10%, but appears to come from both pressure changes and partial volume artifacts. Conclusion: This study demonstrates that alginate spheres with microbubbles can be used as an MRI contrast agent to measure pressure changes. The peristaltic movement within the stomach is seen to substantially alter the overall signal intensity of the contrast agent meal. Future work must focus on improving the contrast agent's sensitivity to pressure changes

Development of a new real-time PCR for the detection of pilchard orthomyxovirus (POMV) in apparently healthy fish

Pilchard orthomyxovirus (POMV) is a virus of concern to the Atlantic salmon aquaculture industry in Tasmania. First isolated from wild pilchards in southern Australia in 1998, the virus is now a recognised pathogen of farmed Atlantic salmon (Salmo salar) in Tasmania. While the current real-time PCR for POMV targets segment 5 of the viral genome, recent viral gene expression data suggests that other segments of the POMV genome presented higher transcription levels and thus may be better candidates for the early detection of the virus. This study aimed to design and begin validating a more sensitive reverse transcriptase real-time PCR (RT-qPCR) assay to detect POMV. Primers and probes were developed targeting two independent viral genes derived from segments 7 and 8, which presented higher transcription levels than segment 5 in both cell culture and infected fish. These were compared with the current POMV RT-qPCR. The POMV segment 8 assay had a higher analytical sensitivity than segment 7, detecting at least 1 plasmid copy μl−1, and was 10-fold more sensitive than both POMV segment 7 and 5 assays when analysing nucleic acid from a positive field sample. Both new assays also had high analytical specificity, detecting the 11 POMV isolates tested (inclusivity testing) and not amplifying nucleic acids from other viruses, including ISAV, a related orthomyxovirus. In the latent class model analysis, the diagnostic sensitivity of the segment 8 and 7 assays were higher than segment 5 in 93% and 92% of simulations, respectively. Seven samples (18.4%), all from subclinical fish infected with POMV, returned a positive result only with the segment 8 assay. Both new assays showed reproducible results when applied to aliquots of the same samples tested in three different laboratories. The new POMV segment 8 assay shows promising results as a surveillance tool for detecting POMV in fish without any symptoms.publishedVersio

Effect of bread gluten content on gastrointestinal function : a crossover MRI study on healthy humans

Gluten is a crucial functional component of bread, but the effect of increasing gluten content on gastrointestinal (GI) function remains uncertain. Our aim was to investigate the effect of increasing gluten content on GI function and symptoms in healthy participants using the unique capabilities of MRI. A total of twelve healthy participants completed this randomised, mechanistic, open-label, three-way crossover study. On days 1 and 2 they consumed either gluten-free bread (GFB), or normal gluten content bread (NGCB) or added gluten content bread (AGCB). The same bread was consumed on day 3, and MRI scans were performed every 60 min from fasting baseline up to 360 min after eating. The appearance of the gastric chime in the images was assessed using a visual heterogeneity score. Gastric volumes, the small bowel water content (SBWC), colonic volumes and colonic gas content and GI symptoms were measured. Fasting transverse colonic volume after the 2-d preload was significantly higher after GFB compared with NGCB and AGCB with a dose-dependent response (289 (SEM 96) v. 212 (SEM 74) v. 179 (SEM 87) ml, respectively; P=0\ub702). The intragastric chyme heterogeneity score was higher for the bread with increased gluten (AGCB 6 (interquartile range (IQR) 0\ub75) compared with GFB 3 (IQR 0\ub75); P=0\ub7003). However, gastric half-emptying time was not different between breads nor were study day GI symptoms, postprandial SBWC, colonic volume and gas content. This MRI study showed novel mechanistic insights in the GI responses to different breads, which are poorly understood notwithstanding the importance of this staple food

Stimulation of colonic motility by oral PEG electrolyte bowel preparation assessed by MRI : comparison of split vs single dose

Peer reviewe

Cross-Language Plagiarism Detection

Cross-language plagiarism detection deals with the automatic identification and extraction of plagiarism in a multilingual setting. In this setting, a suspicious document is given, and the task is to retrieve all sections from the document that originate from a large, multilingual document collection. Our contributions in this field are as follows: (1) a comprehensive retrieval process for cross-language plagiarism detection is introduced, highlighting the differences to monolingual plagiarism detection, (2) state-of-the-art solutions for two important subtasks are reviewed, (3) retrieval models for the assessment of cross-language similarity are surveyed, and, (4) the three models CL-CNG, CL-ESA and CL-ASA are compared. Our evaluation is of realistic scale: it relies on 120,000 test documents which are selected from the corpora JRC-Acquis and Wikipedia, so that for each test document highly similar documents are available in all of the six languages English, German, Spanish, French, Dutch, and Polish. The models are employed in a series of ranking tasks, and more than 100 million similarities are computed with each model. The results of our evaluation indicate that CL-CNG, despite its simple approach, is the best choice to rank and compare texts across languages if they are syntactically related. CL-ESA almost matches the performance of CL-CNG, but on arbitrary pairs of languages. CL-ASA works best on "exact" translations but does not generalize well.This work was partially supported by the TEXT-ENTERPRISE 2.0 TIN2009-13391-C04-03 project and the CONACyT-Mexico 192021 grant.Potthast, M.; Barrón Cedeño, LA.; Stein, B.; Rosso, P. (2011). Cross-Language Plagiarism Detection. Language Resources and Evaluation. 45(1):45-62. https://doi.org/10.1007/s10579-009-9114-zS4562451Ballesteros, L. A. (2001). Resolving ambiguity for cross-language information retrieval: A dictionary approach. PhD thesis, University of Massachusetts Amherst, USA, Bruce Croft.Barrón-Cedeño, A., Rosso, P., Pinto, D., & Juan A. (2008). On cross-lingual plagiarism analysis using a statistical model. In S. Benno, S. Efstathios, & K. Moshe (Eds.), ECAI 2008 workshop on uncovering plagiarism, authorship, and social software misuse (PAN 08) (pp. 9–13). Patras, Greece.Baum, L. E. (1972). An inequality and associated maximization technique in statistical estimation of probabilistic functions of a Markov process. Inequalities, 3, 1–8.Berger, A., & Lafferty, J. (1999). Information retrieval as statistical translation. In SIGIR’99: Proceedings of the 22nd annual international ACM SIGIR conference on research and development in information retrieval (vol. 4629, pp. 222–229). Berkeley, California, United States: ACM.Brin, S., Davis, J., & Garcia-Molina, H. (1995). Copy detection mechanisms for digital documents. In SIGMOD ’95 (pp. 398–409). New York, NY, USA: ACM Press.Brown, P. F., Della Pietra, S. A., Della Pietra, V. J., & Mercer R. L. (1993). The mathematics of statistical machine translation: Parameter estimation. Computational Linguistics, 19(2), 263–311.Ceska, Z., Toman, M., & Jezek, K. (2008). Multilingual plagiarism detection. In AIMSA’08: Proceedings of the 13th international conference on artificial intelligence (pp. 83–92). Berlin, Heidelberg: Springer.Clough, P. (2003). Old and new challenges in automatic plagiarism detection. National UK Plagiarism Advisory Service, http://www.ir.shef.ac.uk/cloughie/papers/pas_plagiarism.pdf .Dempster A. P., Laird N. M., Rubin D. B. (1977). Maximum likelihood from incomplete data via the EM algorithm. Journal of the Royal Statistical Society. Series B (Methodological), 39(1), 1–38.Dumais, S. T., Letsche, T. A., Littman, M. L., & Landauer, T. K. (1997). Automatic cross-language retrieval using latent semantic indexing. In D. Hull & D. Oard (Eds.), AAAI-97 spring symposium series: Cross-language text and speech retrieval (pp. 18–24). Stanford University, American Association for Artificial Intelligence.Gabrilovich, E., & Markovitch, S. (2007). Computing semantic relatedness using Wikipedia-based explicit semantic analysis. In Proceedings of the 20th international joint conference for artificial intelligence, Hyderabad, India.Hoad T. C., & Zobel, J. (2003). Methods for identifying versioned and plagiarised documents. American Society for Information Science and Technology, 54(3), 203–215.Levow, G.-A., Oard, D. W., & Resnik, P. (2005). Dictionary-based techniques for cross-language information retrieval. Information Processing & Management, 41(3), 523–547.Littman, M., Dumais, S. T., & Landauer, T. K. (1998). Automatic cross-language information retrieval using latent semantic indexing. In Cross-language information retrieval, chap. 5 (pp. 51–62). Kluwer.Maurer, H., Kappe, F., & Zaka, B. (2006). Plagiarism—a survey. Journal of Universal Computer Science, 12(8), 1050–1084.McCabe, D. (2005). Research report of the Center for Academic Integrity. http://www.academicintegrity.org .Mcnamee, P., & Mayfield, J. (2004). Character N-gram tokenization for European language text retrieval. Information Retrieval, 7(1–2), 73–97.Meyer zu Eissen, S., & Stein, B. (2006). Intrinsic plagiarism detection. In M. Lalmas, A. MacFarlane, S. M. Rüger, A. Tombros, T. Tsikrika, & A. Yavlinsky (Eds.), Proceedings of the European conference on information retrieval (ECIR 2006), volume 3936 of Lecture Notes in Computer Science (pp. 565–569). Springer.Meyer zu Eissen, S., Stein, B., & Kulig, M. (2007). Plagiarism detection without reference collections. In R. Decker & H. J. Lenz (Eds.), Advances in data analysis (pp. 359–366), Springer.Och, F. J., & Ney, H. (2003). A systematic comparison of various statistical alignment models. Computational Linguistics, 29(1), 19–51.Pinto, D., Juan, A., & Rosso, P. (2007). Using query-relevant documents pairs for cross-lingual information retrieval. In V. Matousek & P. Mautner (Eds.), Lecture Notes in Artificial Intelligence (pp. 630–637). Pilsen, Czech Republic.Pinto, D., Civera, J., Barrón-Cedeño, A., Juan, A., & Rosso, P. (2009). A statistical approach to cross-lingual natural language tasks. Journal of Algorithms, 64(1), 51–60.Potthast, M. (2007). Wikipedia in the pocket-indexing technology for near-duplicate detection and high similarity search. In C. Clarke, N. Fuhr, N. Kando, W. Kraaij, & A. de Vries (Eds.), 30th Annual international ACM SIGIR conference (pp. 909–909). ACM.Potthast, M., Stein, B., & Anderka, M. (2008). A Wikipedia-based multilingual retrieval model. In C. Macdonald, I. Ounis, V. Plachouras, I. Ruthven, & R. W. White (Eds.), 30th European conference on IR research, ECIR 2008, Glasgow , volume 4956 LNCS of Lecture Notes in Computer Science (pp. 522–530). Berlin: Springer.Pouliquen, B., Steinberger, R., & Ignat, C. (2003a). Automatic annotation of multilingual text collections with a conceptual thesaurus. In Proceedings of the workshop ’ontologies and information extraction’ at the Summer School ’The Semantic Web and Language Technology—its potential and practicalities’ (EUROLAN’2003) (pp. 9–28), Bucharest, Romania.Pouliquen, B., Steinberger, R., & Ignat, C. (2003b). Automatic identification of document translations in large multilingual document collections. In Proceedings of the international conference recent advances in natural language processing (RANLP’2003) (pp. 401–408). Borovets, Bulgaria.Stein, B. (2007). Principles of hash-based text retrieval. In C. Clarke, N. Fuhr, N. Kando, W. Kraaij, & A. de Vries (Eds.), 30th Annual international ACM SIGIR conference (pp. 527–534). ACM.Stein, B. (2005). Fuzzy-fingerprints for text-based information retrieval. In K. Tochtermann & H. Maurer (Eds.), Proceedings of the 5th international conference on knowledge management (I-KNOW 05), Graz, Journal of Universal Computer Science. (pp. 572–579). Know-Center.Stein, B., & Anderka, M. (2009). Collection-relative representations: A unifying view to retrieval models. In A. M. Tjoa & R. R. Wagner (Eds.), 20th International conference on database and expert systems applications (DEXA 09) (pp. 383–387). IEEE.Stein, B., & Meyer zu Eissen, S. (2007). Intrinsic plagiarism analysis with meta learning. In B. Stein, M. Koppel, & E. Stamatatos (Eds.), SIGIR workshop on plagiarism analysis, authorship identification, and near-duplicate detection (PAN 07) (pp. 45–50). CEUR-WS.org.Stein, B., & Potthast, M. (2007). Construction of compact retrieval models. In S. Dominich & F. Kiss (Eds.), Studies in theory of information retrieval (pp. 85–93). Foundation for Information Society.Stein, B., Meyer zu Eissen, S., & Potthast, M. (2007). Strategies for retrieving plagiarized documents. In C. Clarke, N. Fuhr, N. Kando, W. Kraaij, & A. de Vries (Eds.), 30th Annual international ACM SIGIR conference (pp. 825–826). ACM.Steinberger, R., Pouliquen, B., Widiger, A., Ignat, C., Erjavec, T., Tufis, D., & Varga, D. (2006). The JRC-Acquis: A multilingual aligned parallel corpus with 20+ languages. In Proceedings of the 5th international conference on language resources and evaluation (LREC’2006).Steinberger, R., Pouliquen, B., & Ignat, C. (2004). Exploiting multilingual nomenclatures and language-independent text features as an interlingua for cross-lingual text analysis applications. In Proceedings of the 4th Slovenian language technology conference. Information Society 2004 (IS’2004).Vinokourov, A., Shawe-Taylor, J., & Cristianini, N. (2003). Inferring a semantic representation of text via cross-language correlation analysis. In S. Becker, S. Thrun, & K. Obermayer (Eds.), NIPS-02: Advances in neural information processing systems (pp. 1473–1480). MIT Press.Yang, Y., Carbonell, J. G., Brown, R. D., & Frederking, R. E. (1998). Translingual information retrieval: Learning from bilingual corpora. Artificial Intelligence, 103(1–2), 323–345

Pentecostal intimacies: women and intimate citizenship in the ministry of repentance and holiness in Kenya

This article explores the intersections of gender, sexuality and citizenship in the context of one prominent neo-Pentecostal movement in Kenya, the Ministry of Repentance and Holiness (MRH) led by the charismatic Prophet David Owuor. Employing the concept of intimate citizenship, the article analyses, first, how MRH engages in a contestation of intimate citizenship in the contemporary Kenyan public sphere, especially in relation to women’s bodies. Second, it examines how MRH simultaneously configures, through a range of highly intimate beliefs, practices and techniques, an alternative form of intimate citizenship defined by moral purity and concerned with a political project of moral regeneration. Coining the notion of ‘Pentecostal intimacies’, the article provides insight into the reasons why so many people, especially women, are attracted to MRH, and hence it interrogates the liberal frame in which intimate citizenship is usually conceptualised

The European Nucleotide Archive

The European Nucleotide Archive (ENA; http://www.ebi.ac.uk/ena) is Europe’s primary nucleotide-sequence repository. The ENA consists of three main databases: the Sequence Read Archive (SRA), the Trace Archive and EMBL-Bank. The objective of ENA is to support and promote the use of nucleotide sequencing as an experimental research platform by providing data submission, archive, search and download services. In this article, we outline these services and describe major changes and improvements introduced during 2010. These include extended EMBL-Bank and SRA-data submission services, extended ENA Browser functionality, support for submitting data to the European Genome-phenome Archive (EGA) through SRA, and the launch of a new sequence similarity search service